Beauty peptides are a burgeoning field of research within the realm of cosmetic chemistry, offering promising applications in the development of innovative skincare products. Peptides, short chains of amino acids, possess unique biochemical properties that make them suitable candidates for targeting specific biological processes involved in skin health and appearance.

Synthesis of Beauty Peptides

The synthesis of beauty peptides often involves solid-phase peptide synthesis (SPPS) techniques, allowing for precise control over the sequence and chemical modifications. Recent advancements in peptide synthesis strategies have enabled the production of increasingly complex peptides, facilitating the design of more targeted and effective skincare formulations.

Function of Beauty Peptides

Enhance Collagen Synthesis

One of the main functions of beauty peptides is their ability to enhance collagen synthesis. Collagen is a protein responsible for providing structural support to the skin. Beauty peptides can stimulate collagen synthesis, resulting in firmer, more youthful-looking skin.

Improve Skin Hydration

Beauty peptides can improve skin hydration by increasing the production of hyaluronic acid, a molecule that can hold up to a thousand times its weight in water. This increased hydration helps to plump the skin, reducing the appearance of fine lines and giving it a smoother, more supple appearance.

Antioxidant Properties

Beauty peptides also have antioxidant properties, protecting the skin from damage caused by free radicals. Free radicals are unstable molecules that can lcause oxidative stress in the skin, leading to premature aging and other skin problems. Beauty peptides with antioxidant properties can help neutralize these free radicals and prevent their damaging effects on the skin.

What Are the Popular Beauty Peptides?

According to the different effects of beauty peptides, here are several beauty peptide series that are most popular in the cosmetics market.

Collagen-Stimulating Peptides

As mentioned earlier, collagen plays a vital role in skin integrity, and its depletion leads to the appearance of wrinkles and sagging skin. Palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl tetrapeptide-7 (Pal-GQPR) are popular collagen-stimulating peptides. They activate cellular signaling pathways responsible for collagen synthesis, stimulating fibroblast activity, and improving skin elasticity.

Antioxidant Peptides

Antioxidant peptides scavenge free radicals, reducing oxidative stress and protecting skin cells from damage. Carnosine and glutathione are well-known peptides with potent antioxidant properties. Carnosine exhibits protective effects against photoaging and UV-induced damage, whereas glutathione inhibits melanin synthesis, thus minimizing hyperpigmentation.

Hyaluronic Acid (HA) Promoting Peptides

Hyaluronic acid is crucial for skin hydration and plumpness. Hyaluronic acid-promoting peptides, such as tripeptide-1 and acetyl tetrapeptide-5, enhance HA synthesis by stimulating hyaluronic acid synthase enzymes. This results in improved moisture retention, skin elasticity, and wrinkle reduction.

Relaxing Peptides

Relaxing peptides, such as hexapeptide-8 (Argireline), work by inhibiting the release of neurotransmitters that cause muscle contractions. This helps to reduce the appearance of wrinkles and fine lines, particularly those caused by repetitive facial movements. These peptides provide a temporary smoothing and relaxing effect on the skin, similar to the results achieved with Botox injections, but without the need for invasive procedures. They are typically used in anti-aging skincare products to target expression lines and promote a more youthful appearance.