The active component of Vidalista 80 mg, tadalafil, inhibits PDE5 in the body. This enzyme breaks down cyclic guanosine monophosphate, an important chemical that promotes smooth muscle relaxation and increased blood flow to the penis during sexual stimulation. Follow the recommended dosage if this drug is being used to treat pulmonary hypertension. Take these drugs at least 30 to 60 minutes before having sex if you're using them to address an erection issue. Follow your doctor's instructions on the amount and timing of these medications. Never consume, smash, or break it. This tablet needs to be taken with food.