Iron Metabolism in Neurodegenerative Diseases
Protein aggregation of α-synuclein and hyperphosphorylated tau proteins in neurodegenerative diseases have been shown to be triggered in vitro by elevated concentrations of trivalent iron. Inclusion bodies containing damaged or aggregated proteins may lead to endoplasmic reticulum stress, a common feature of several neurodegenerative disorders.
Alzheimer's Disease: High levels of...